Is it acceptable in academic publishing to submit two (or more) papers on different topics to the same journal?

The short answer to this question is ‘yes’. ‘Yes, absolutely’.

Yes!

You are free to submit as many papers as you wish to the same journal so long as they are different, the content does not significantly overlap, and the articles don’t contradict one another. What do we mean by ‘different’? Think papers that deal with different experiments, topics, or questions so that the works do no overlap and could therefore be …